New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

DNA is often described as the instruction manual for building the fundamental components of life. Proteins are helpers that ...

“Depleting amino acid[s] likely expose[s] the Achilles heel of the cancer and exacerbate[s] DNA repair-targeted and immune-based therapy response.” “In this prospective, we will rise the driving ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Recently, the research team led by Prof. Junjiu Huang from Sun Yat-sen University, in collaboration with Prof. Fenghua Liu’s team at Guangdong Women and Children Hospital, published a study titled ...