The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...

The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding proteins. Proteins are essential for a wide range of cellular functions—as enzymes, transporters, ...

Aging can begin with an imperceptible restructuring of the "internal factories" of the cell. Scientists have learned that ...

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions ...

Calcium (Ca 2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum (ER), a cellular organelle that synthesizes and transports proteins, has not ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these ...

Researchers reveal how cells regenerate protein factories at endoplasmic reticulum. Researchers at LMU and Stanford University reveal how cells regenerate protein factories at endoplasmic reticulum.

In A Nutshell As cells age, they deliberately shrink a major internal structure called the endoplasmic reticulum. This downsizing happens early in adulthood and shifts cells away from protein ...

Er Stress Research Institute Inc. has disclosed benzothiazoimidazolyl compounds acting as endoplasmic reticulum (ER) stress inhibitors reported to be useful for the treatment of cancer, diabetes, ...

Researchers have now discovered that DNA sequence changes known to increase a person's risk for diabetes are linked to how well pancreatic cells can handle two different kinds of molecular stress. In ...