The endoplasmic reticulum (ER) is central to protein synthesis, folding and modification, ensuring that the proteome of a cell remains functional and balanced. When the ER is overwhelmed by an ...
Endoplasmic reticulum oxidoreductase 1 (ERO1) has traditionally been associated with proper protein folding in the endoplasmic reticulum, but it has recently been linked to platelet activation and ...
While we often think of diseases as caused by foreign bodies -- bacteria or viruses -- there are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A ...
The discovery of a puddle of mouse urine seems like a strange scientific "eureka" moment. However, for one team of researchers, that's exactly what led to a new discovery. The researchers' findings ...
In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers at the University of Basel have now discovered tiny “folding factories” in cells that enable ...
There are hundreds of diseases affecting humans that result from errors in cellular production of its proteins. A team led by researchers at the University of Massachusetts, Amherst, report they ...
The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...
A surprising finding from USC reveals key details about how cancer cells metastasize and suggests new therapeutic approaches for halting their spread. Lee and her colleagues have now made an ...
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