Effect of indoximod-based chemo-immunotherapy in patients with pediatric brain tumors on activation and clonal proliferation of a circulating population of early non-exhausted stem-like CD8+ T cells ...

Clonal hematopoiesis (CH), the benign clonal expansion of hematopoietic stem cells, is often caused by somatic sequence variations in genes associated with hematologic malignancies. Over the past ...

Patients with solid tumors, such as breast and gastrointestinal cancers, who also have clonal hematopoiesis of indeterminate potential could have a significantly higher risk for cardiovascular disease ...

Hematopoiesis is the production of all of the cellular components of blood and blood plasma. It occurs within the hematopoietic system, which includes organs and tissues such as the bone marrow, liver ...

In 1962, Pitcock et al 12 published their findings in adults with myelofibrosis. Renal extramedullary hematopoiesis was recognized in 35% of autopsies. In this series of 17 complete autopsies, the ...

The decrease in the incidence of cardiovascular disease and the improved prognosis in persons with a diagnosis of cardiovascular disease are due, in part, to the development of new treatments based on ...

Outcomes of Childhood Noninfant Acute Lymphoblastic Leukemia With 11q23/KMT2A Rearrangements in a Modern Therapy Era: A Retrospective International Study Among 200,629 UK Biobank (UKBB) participants ...

Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production. 1 Clonal hematopoiesis ...

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In a recent study published in the journal Nature Genetics, a team of researchers from the United Kingdom (U.K.) and the United States (U.S.) analyzed whole blood samples from a large cohort of U.K.