When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory ...

A new study shows type I interferon fine-tunes macrophage mitochondria through the protein ISG15, boosting dead-cell ...

Study findings map out a new way in which antiviral signals engage with cellular metabolism to balance defense and repair.

Mitochondrial DNA has long been treated as a workhorse record of cellular history, but new research suggests it also hides a subtle and previously overlooked form of damage. By uncovering this cryptic ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

The structural and functional characteristics of mitochondria shape their role as signaling organelles, with far-reaching ...

Ocean pollution is quietly draining energy from seabirds’ cells, as mercury and forever chemicals disrupt mitochondria even ...

The tiny little powerhouses of our cells: mitochondria, are unique among organelles because they carry their own tiny little genomes. This genetic material is separate from the rest of our genomic DNA ...

Summary of the effect of mammalian mtDNA on contributing 13 polypeptide subunits (PS) to five oxidative phosphorylation complexes (I–V) that make up the OXPHOS. The inner mitochondrial membrane ...