Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

When our body fights an infection, the immune system must quickly activate defenses and trigger a beneficial inflammatory response. But it is just as important to resolve that inflammation and return ...

The nuclear envelope (NE) is a dynamic and selective barrier that organizes genome function and nucleocytoplasmic ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

Study findings map out a new way in which antiviral signals engage with cellular metabolism to balance defense and repair.

Summary of the effect of mammalian mtDNA on contributing 13 polypeptide subunits (PS) to five oxidative phosphorylation complexes (I–V) that make up the OXPHOS. The inner mitochondrial membrane ...

A previously unknown type of DNA damage in the mitochondria, the tiny power plants inside our cells, could shed light on how our bodies sense and respond to stress. The findings of the UC ...

A new study shows type I interferon fine-tunes macrophage mitochondria through the protein ISG15, boosting dead-cell ...

Ocean pollution is quietly draining energy from seabirds’ cells, as mercury and forever chemicals disrupt mitochondria even ...