Researchers at Indiana University Bloomington have developed allosteric modulators of the opioid receptor that were superior to the opioid antidote naloxone at blocking the effects of fentanyl in ...

Having a pill that alleviates chronic pain without adverse side effects or the risk of addiction remains an unmet pharmaceutical need for millions of people currently using traditional opioid drugs.

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Two different versions of the mu-opioid receptor within a cellular membrane illustrate how the receptor changes its conformation to send a signal into the cell. Scientists captured six high-resolution ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky enough to fuel a global overdose crisis. Now a wave of basic science and ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Opioid medications offer people relief from debilitating pain, but these drugs are associated with the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

Brandy Schillace’s review of “Candace Pert” by Pamela Rykman (Bookshelf, Nov. 15) contains a questionable conclusion: the discovery of the mu opioid receptor in 1972 “helped launch the opioid crisis” ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...