Linkage disequilibrium (LD) refers to the correlation among neighboring alleles, reflecting common haplotype ancestry. In the May 10 Nature, Reich et al. describe a systematic, genome-wide analysis of ...

The promise of pharmacogenetics will not be realized easily. To date, most studies have focused on individual SNPs (single nucleotide polymorphisms), or perhaps a few, but none have considered the ...

This practical is based on using the software package GCTA to estimate the heritability of a trait for which causal SNP effects depend on allele frequency and linkage disequilibrium patterns (Lecture ...