Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Sep 26, 2024 · The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in co-cultures of …
Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface
Nov 4, 2023 · The biggest surprise was where these cells are. Contrary to conventional wisdom, which held that glia limitans astrocytes reside in the parenchyma and extend end feet upward to form the …
Glial lipid droplets resolve ROS during sleep. | ALZFORUM
Feb 27, 2024 · Most previous work on this process focused on disease conditions. However, Haynes and colleagues discovered that glial lipid droplet accumulation occurs as part of a daily rhythm: in …
“iAssembloids” Probe Glial Roles in Neuron Survival
Jan 24, 2025 · Interestingly, they discovered that this axis is undetectable in 2D or even 3D neuron monoculture models, highlighting the need for more sophisticated models replicating physiological …
Scutellaria barbata flavonoids improve the composited Aβ-induced ...
Dec 20, 2020 · Cheng JJ, Guo Q, Wu XG, Ma S, Gao Y, Ya-Zhen S. Scutellaria barbata flavonoids improve the composited Aβ-induced abnormal changes of glial cells in rats' brain.
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh the Brain ...
Feb 27, 2024 · Further, neuronal but not glial mitochondria became oxidized. This suggests that neurons were indeed the source of the peroxidated lipids and that, by shuttling them to glia, neurons …
Tau is required for glial lipid droplet formation and resistance to ...
Oct 22, 2024 · This very interesting finding describes a novel function for tau in the processing of peroxidated lipids from neurons. We previously showed that these lipids are transferred from …
Glial AP1 is activated with aging and accelerated by ... - ALZFORUM
Byrns CN, Saikumar J, Bonini NM. Glial AP1 is activated with aging and accelerated by traumatic brain injury. Nat Aging. 2021 Jul;1 (7):585-597. Epub 2021 Jul 8 PubMed.
Glial and neuronal control of brain blood flow. | ALZFORUM
Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010 Nov 11;468 (7321):232-43. PubMed.